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中文摘要：
依据甘油连续发酵生产1,3-丙二醇的非线性酶催化动力系统.针对1,3-丙二醇可能存在的跨膜运输方式建立相应的动力学模型,提出了酶催化动力系统的定量鲁棒性定义,并建立了以鲁棒性为性能指标、非线性动力系统为主要约束的参数辨识模型.由于求解该辨识问题的数值计算量大,在普通的PC机上难以完成,因此本文构建了相应的并行算法.根据数值结果推断出1,3-丙二醇最有可能的跨膜运输方式,这对于进一步研究甘油连续发酵的机理具有重要的参考价值.
英文摘要：
In this paper,the non-linear enzyme-catalytic kinetic system of continuous fermentation in the process of glycerol bio-dissimilation is investigated.We establish various dynamical systems according to the possible transport mechanisms of 1,3-propanediol across cell membrane.We propose a new quantitative robustness index for the considered systems,which, together with the relative error between experimental data and computational results,is taken as a performance index for the subsequent identification model.The identification problem is composed of discrete and continuous variables and subjected to the constraint of complex nonlinear dynamical systems.Since the calculation effort of the identification problem exceeds the calculation capability of personal computer,a parallelalgorithm procedure is constructed to solve the parameter identification model,and subsequently the most possible transport mechanism of 1,3- propanediol is given.This work will be helpful for deeply understanding the metabolic mechanism of glycerol in continuous fermentation.
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