欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
提出了一种新颖的复杂疾病驱使的融合SDA-SVM（Stepwise Discriminant Analysis-Support Vector Machine,SDA-SVM）技术的集成基因挖掘方法。该集成方法融合逐步判别分析和支持向量机的优点,能够有效地进行复杂疾病相关基因的深度挖掘,使得挖掘出的基因能够较好地识别疾病类型和亚型。通过将该方法应用于一套弥散性大B细胞淋巴瘤DNA表达谱数据,并与其它基因挖掘方法对比,结果表明该方法挖掘出的基因具有较高的疾病相关性和较强的疾病类型识别能力。
英文摘要：
This paper proposes a novel ensemble approach which combines the merits of stepwise discriminant analysis and support vector machine for extracting disease relevant genes and for classifying biological types.By comparing the proposed method with other gene mining methods using a public dataset of the diffuse large b-cell lymphoma,the result demonstrates that the genes extracted by the proposed method have higher disease relevancy and also yield better classification performance.
同期刊论文项目
同项目期刊论文
An analysis-of-variance (ANOVA) approach for sib-pair linkage analysis of complex ordinal human dise
Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approa
Gene mining: a novel and powerful ensemble decision approach to hunting for disease genes using micr
A robust hybrid between genetic algorithm and support vector machine for extracting an optimal featu
Effects of replacing the unreliable cDNA microarray measurements on the disease classification based
Peeling off the hidden genetic heterogeneities of cancers based on disease-relevant functional modul
Identifying disease feature genes based on cellular localized gene functional modules and regulation
An analysis of gene expression relationships between periodically expressed genes in the Hela cells.
AUNX1, a novel locus responsible for X-linked recessive and early-onset auditory neuropathy in an ex
An LRP8 Variant Is Associated with Familial and Premature Coronary Artery Disease and Myocardial Inf
A feature ensemble technology to identify molecular mechanisms for distinction between multiple subt
A systematic method for mapping multiple loci: an application to construct a genetic network for rhe
GJB2, SLC26A4 and mitochondrial DNA A1555G mutations in prelingual deafness in Northern Chinese subj
Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers hig
Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Itali
Constructing disease-specific gene networks using pair-wise relevance metric: application to colon c
Prioritizing Risk Pathways: A Novel Association Approach to Searching for Disease Pathways Fusing SN
Decision Forest Analysis of Large-scale Sib-pair Identical-by-decent Profiles for Locating the Under
期刊信息
位置：