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中文摘要：
目的：探讨糖尿病视网膜病变（diabetic retinopathy，DR）患者血浆内皮素1（endothelin-1，ET-1）、降钙素基因相关肽（calcium gene related peptide，CGRP）的水平变化，以阐明其在糖尿病并发视网膜病变中的作用。 方法：应用放射免疫分析（RIA）检测123例DR患者和157例对照组（未并发DR）患者血浆ET-1，CGRP的浓度。 结果：病例组的患者的血浆ET-1（186．2±44．0ng／L），CGRP（46．4±13．3ng／L）与对照组（135．3±28．1ng／L）和（73．2±19．6ng／L）相比较，差异均有显著性意义（P〈0．01）。而非增殖型与增殖型患者对照比较亦有显著性差异（P〈0．05）。增殖型患者血浆ET-1，CGRP水平呈负相关（r=-0．679，P〈0．05）。 结论：ET-1和CGRP在DR发病过程中可能有着重要的病理作用，并且与DR病变严重程度有着一定的关联，血浆含量检测有助于判断病情的程度。
英文摘要：
AIM ： To illustrate the effects of endothelin-1 （ ET-1 ） and calcitonin gene related peptide （CGRP） in patients with diabetic retinopathy （DR） through investigation of the changes of the plasma levels of ET-1 and CGRP. METHODS： Plasma ET-1 and CGRP concentrations were measured with RIA in 123 patients with DR and 157 controls. RESULTS： Plasma ET-1（186.2±44.0ng/L） and CGRP （46.4 ±13.3ng/L） levels in the patients with DR were significantly different from those in the controls （ET-1： 135.3±28.1ng/L, CGRP： 73.3 ± 19.6ng/L, P〈0.01）. Differences between the levels of these non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were also significant （ P 〈 0. 05）. In patients with proliferative diabetic retinopathy, the plasma ET-1 levels were negtively correlated to the plasma CGRP levels （r= -0.679, P〈O.05）. CONCLUSION： Plasma ET-1 and CGRP play important role in the whole patho-physiologic process of DR and correlate to the severity of the disease, measuements of their plasma concentrations help to predict theseverity of the disease.
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