目的观察小青龙汤加味联合西医治疗支气管哮喘寒哮证疗效及对肺功能的影响。方法将100例支气管哮喘寒哮证患者随机分为对照组与观察组,每组50例。对照组给予西医治疗,观察组在对照组基础上给予小青龙汤加味治疗,观察2组治疗效果、用药安全性、治疗前后肺功能指标水平、中医症状积分变化情况。结果治疗1个疗程后,观察组治疗总有效率为90%,显著高于对照组的70%(P〈0.05);观察组治疗后的各项中医症状积分值均显著低于对照组(P〈0.05),而肺功能指标中第1秒最大呼气量(FEV,)、第1秒最大呼气量占用力肺活量的比值(FEV1/FVC)、最大呼气峰流速值(PEF)均显著高于对照组(P均〈0.05);2组不良反应发生率比较差异无统计学意义(P〉0.05)。结论小青龙汤加味联合西医治疗支气管哮喘寒哮证患者可提高临床疗效,改善肺功能,且安全可靠,值得推广应用。
Objective It is to observe the curative effect of Xiaoqinglong decoction combined with western medicine on bronchial asthma of cold asthma type and lung function. Methods 100 patients with bronchial asthma of cold asthma type were randomly divided into control group and observation group, each group had 50 cases. The control group was treated with west- ern medicine, while the observation group was given Xiaoqinglong decoction on the basis of therapy in control group. The clinical effect, therapy safety, the changes of lung function indexes and scores of traditional Chinese medical symptoms before and after treatment in both groups were observed. Results After one course of treatment, the total effective rate was 90% in observation group, which was higher than that in control group (70%) (P 〈 0.05). The scores of symptom were significantly lower, while FEV1, FEV1/FVC, PEF were higher after treatment in observation group than those in control group(P 〈 0.05 ). There was no significant difference in incidence of side effect between the two groups (P 〉 0.05 ). Conclusion Xiaoqinglong decoction combined with western medicine can improve clinical curative effect and lung function with good safety and reliability in the treatment of bronchial asthma of cold asthma type.