欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
受体型蛋白质酪氨酸磷酸酶α（receptor-type protein tyrosine phosphataseα,RPTPα）是一种广泛表达的膜受体,在细胞生长、细胞分化、细胞周期及肿瘤发生中起着重要调控作用。该文从RPTPα的基因基本结构特征、受体二聚化及RPTPα-c-Src和整合蛋白介导的信号转导通路等方面对RPTPα的生物学特性进行了阐述,并重点总结了RPTPα在结直肠癌、乳腺癌、胃癌等肿瘤发生中的主要促癌作用,归纳了RPTPα在不同肿瘤中介导的主要信号转导途径及其在相关信号转导通路中的功能。在此基础上,该文提出了今后可能的研究方向。
英文摘要：
Receptor-type protein tyrosine phosphatase α（RPTPα）, a member of receptor-type protein tyrosine phosphatase（PTP） family, is widespread in cells, functioning as an important regulator in a variety of cellular processes, such as cell growth, differentiation, mitotic cycle, oncogenic transformation and so on. In this review, the fundamental properties of RPTPα, receptor dimerization and relative signal transduction pathway such as RPTPα-c-Src and integrin signaling are discussed to illuminate the molecular functions of RPTPα. Furthermore, current research progress of RPTPα and its relative signaling pathway in the oncogenesis of rectal cancer, breast cancer, gastric cancer is summarized specially. Based on that, this review proposes the direction for the subsequent study.
同期刊论文项目
同项目期刊论文
期刊信息
位置：