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中文摘要：
目的探讨超敏C反应蛋白（high-sensitivity C-reactive protein,Hs-CRP）、血清半胱氨酸（homo-cysteine,Hcy）和低密度脂蛋白/高密度脂蛋白比值（low-density lipoprotein cholesterol/high-density lipopro-tein cholesterol ratio,LDL-C/HDL-C）联合检测对冠状动脉粥样硬化性心脏病（coronary heart disease,CHD）的诊断价值。方法选取2008年7月～2010年12月入院接受冠状动脉造影术检查患者264例,冠心病组165例,对照组（冠脉造影正常）99例,分别测定各组血清中Hs-CRP、Hcy和LDL-C/HDL-C的水平。结果冠心病组Hs-CRP、Hcy的含量和LDL-C/HDL-C比值均显著高于对照组（P〈0.01）。联合应用Hs-CRP、Hcy和LDL-C/LDL-C对冠心病的诊断敏感度（94.5%）高于分别单独应用Hs-CRP（85.6%）、Hcy（82.3%）和TC/HDL-C（76.2%）的诊断敏感度（P〈0.05）。结论联合应用Hs-CRP、Hcy和LDL-C/HDL-C更有助于冠心病的早期诊断。
英文摘要：
Objective To study the value of integrated detection of serum high-sensitivity C-reactive protein（Hs-CRP）,homocysteine（Hcy）and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio（LDL-C/HDL-C）in diagnosis of coronary heart disease（CHD）.Methods Hs-CRP,Hcy and LDL-C/HDL-C ratio were analyzed in 165 cases of patient（CHD group） and 99 cases of control（control group）which were enrolled by coronary angiography.Results The concentration of Hs-CRP,Hcy and LDL-C/HDL-C ratio were significantly higher in CHD patients than those in control group（P0.01）.The sensitivity of integrated detection of all the three markers（92.8%） was higher than the single marker detection of either Hs-CRP（83.7%）,Hcy（80.0%）or LDL-C/HDL-C（73.4%）,P0.05.Conclusion Integrated detection of Hs-CRP,Hcy and LDL-C/HDL-C is more accurate and reliable in the diagnosis of CHD.
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