中文摘要：

目的：研究不同中医治法对帕金森病（Parkinson＇s disease,PD）大鼠神经行为学的影响。方法：采用经典的6-羟基多巴胺损毁注射法制作PD模型,将成功模型大鼠随机分为5组,其中4组分别应用活血化瘀法（代表方桃红四物汤）、涤痰熄风法（代表方涤痰汤）、滋阴熄风法（代表方天麻钩藤饮）和复合治法（代表方自拟复方地黄方）等不同治法方药进行治疗,另1组作为模型组应用生理盐水治疗。治疗结束后使用阿扑吗啡（APO）诱导旋转行为,并进行各组治疗前后和各药物治疗组间的旋转圈数比较。结果：模型组治疗前后旋转圈数比较差异无统计学意义（P〉0.05）;其余各治疗组旋转圈数前后比较差异有统计学意义（P〈0.05或P〈0.01）。天麻钩藤饮组与桃红四物汤组、涤痰汤组比较,旋转圈数差异有统计学意义（P〈0.05）;复方地黄汤组与桃红四物汤组、涤痰汤组比较,旋转圈数差异有统计学意义（P〈0.01）。天麻钩藤饮组与复方地黄汤组比较,旋转圈数差异无统计学意义（P〉0.05）。结论：各种中医治法均有明显的抗PD大鼠的旋转行为的作用,但以天麻钩藤饮为代表方的滋阴熄风法和以自拟复方地黄方为代表方的复合治法效果较好。根据以方测证的原理,该类帕金森病的大鼠模型的中医证候属性与阴虚类证最为接近,兼有痰、瘀的因素,应用复合治法的方药治疗帕金森病是值得探索的研究方向。

英文摘要：

Objective：To investigate the influence of Different Therapeutic Methods in TCM on neurological behavior of PD rat model.Methods：Made the PD Rat Model in the classic damaging methods of injecting 6-OHDA.To apply several diffirennt kinds chinese medical formulases to treat the model.The therapeutic method of Ziyin Xifeng was presented by Tianma Gouteng Decoction;The therapeutic method of Huoxue Huayu was presented by Taohong Siwu Decoction;The therapeutic method of Ditan Xifeng was presented by Ditan Decoction;The complex therapeutic method was presented by Complex Dihuang Decoction.Observed the neurological behavior changes in different PD rats groups,and compared with the model group therapied by physiological saline.After treatment,made the compares of rotation behavior rounds induced by APO between pre and post treatment and among the several groups Chinese.Results：The rotation behavior rounds of model group was not statistically significant（P 0.05） between pre and post treatment;All the others were statistically significant （P 0.05,or P 0.01） between pre and post treatment.After treatment,compared Tianma Gouteng Decoction group with Taohong Siwu Decoction group or Decoction Ditan Decoction grpup,the rotation behavior rounds were statistically significant （P 0.05） ;compared Complex Dihuang Decoction with Taohong Siwu Decoction group or Decoction Ditan Decoction group,the rotation behavior rounds were statistically significant （P 0.01） ;Compared Complex Dihuang Decoction with Tianma Gouteng Decoction group,the rotation behavior rounds was statistically significant （P 0.05）.Conclusion：Every therapeutic Methods in TCM had the effects of decreasing the rotation behavior rounds of PD model rats,but the complex TCM therapy and Ziyin Xifeng therapy had the best effect.According to the principle of syndromes＇ property counterevidenced by using the chinese medical formulary therapy,The Syndrome property of PD rat models made by 6-OHDA was mainly Yin deficiency inducing to the ＂Dongfeng＂