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核磁共振氢谱研究氯化镧对大鼠脑中代谢物的影响
  • 期刊名称：中国稀土学报. 39 (增刊). 171-173, 2006
  • 时间：0
  • 分类：O614.3[理学—无机化学;理学—化学]
  • 作者机构：[1]中国科学院高能物理研究所多学科研究中心,中国科学院核分析技术重点实验室,北京,100049 中国科学院高能物理研究所多学科研究中心,中国科学院核分析技术重点实验室,北京,100049 中国科学院高能物理研究所多学科研究中心,中国科学院核分析技术重点实验室,北京,100049 中国科学院波谱与原子分子物理国家重点实验室,湖北,武汉,430071 中国科学院波谱与原子分子物理国家重点实验室,湖北,武汉,430071
  • 相关基金：国家自然科学基金重大项目(10490181);波谱与原子分子物理国家重点实验室基金(T152401)资助
  • 相关项目：重金属汞和稀土的毒理
关键词： 脑, 代谢物, 核磁共振, 毒性, 稀土
中文摘要：

采用核磁共振技术研究了氯化镧对大鼠脑中代谢物的影响.雄性SD大鼠尾静脉注射剂量为0.1 mmol·kg-1体重的氯化镧溶液,分别在注射后2和4 h处死大鼠,提取脑中水溶性代谢物.分析结果表明,氯化镧引起部分代谢物含量的变化,4 h组琥珀酸、谷氨酸和γ-氨基丁酸含量与对照组相比分别下降32%,7%和16%,这表明静脉注射氯化镧可能引起脑功能的变化.

同期刊论文项目
重金属汞和稀土的毒理
期刊论文 104 会议论文 70
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