中文摘要：

目的探讨伴有及不伴常见非器官特异性自身抗体的视神经脊髓炎谱系疾病（NMOSD）患者的临床特点。方法收集36例NMOSD患者,其中伴有常见非器官特异性自身抗体者26例（阳性组）,不伴常见非器官特异性自身抗体者10例（阴性组）,比较两组临床表现、实验室检查及影像学特点。结果 36例NMOSD患者中伴有至少一种常见非器官特异性自身抗体者占72.22%,并以抗核抗体、抗SSA抗体、抗Ro-52抗体为主。阳性组患者发病年龄晚于阴性组,且更易合并非器官特异性自身免疫疾病及肿瘤;阴性组患者首发症状中,视神经炎/脊髓炎比例明显高于阳性组,而阳性组的脑脊液压力及蛋白含量均明显高于阴性组;两组间其他临床、实验室及病灶分布特点相似。结论伴有常见非器官特异性自身抗体的NMOSD患者中枢神经系统炎症反应更严重,更易合并非器官特异性自身免疫疾病及肿瘤。

英文摘要：

Objective To investigate and compare the features between neuromyelitis optica spectrum disorders（ NMOSD） with and without common non-organ-specific autoantibodies. Methods A total of 36 NMOSD patients were divided into 2 groups： positive group（ n = 26,with common non-organ-specific autoantibodies）,and negative group（ n = 10,without common non-organ-specific autoantibodies）. The clinical,laboratory and imaging features between the two groups were assessed. Results Common non-organ-specific autoantibodies in NMOSD patients were mainly antinuclear antibody,anti-SSA antibody and anti-Ro52 antibody. The age of onset of the patients in the positive group were older than those in the negative group,and tended to complicate with non-organ-specific autoimmune diseases or tumors. As the initial symptoms,the ratio of optic neuritis / myelitis was higher in the negative group. While the cerebrospinal pressure and protein content were higher in the positive group. No differences were observed in other clinical,laboratory or MRI characteristics between the two groups. Conclusions NMOSD patients with non-organ-specific autoantibodies are vulnerable to severe inflammation in the central nervous system,non-organ-specific autoimmune diseases and tumors.