中文摘要：

背景：骨骼肌占了人体总体质量的40%，然而许多骨骼肌损伤和疾病的机制问题尚未解决。MicroRNA-206（miR-206）是骨骼肌特异性miRNA，在骨骼肌的发育和再生中起着重要的作用。目的：总结分析microRNA-206在骨骼肌损伤和疾病中的研究现状。方法：以“miR-206, skeletal muscle”为检索词，计算机检索1992至2014年PubMed数据库相关文献的全文，经过筛选最终对60篇miR-206在骨骼肌损伤和疾病中的相关研究进行分析讨论。结果与结论：MiR-206能调节神经肌肉损伤后神经肌肉接点的恢复。相关研究显示，控制miR-206水平可能成为治疗肌萎缩侧索硬化症等肌肉疾病的新方法。通过细胞培养发现miR-206能促进卫星细胞的分化，缺乏miR-206会导致卫星细胞延迟分化，在骨骼肌损伤中也发现miR-206能促进骨骼肌的再生。miR-206长期运动适应后水平下降，但当运动适应停训一段时间后，miR-206会恢复到原先的水平，而其机制还有待研究。

英文摘要：

BACKGROUND：Skeletal muscle accounts for 40%of total body weight, but mechanisms of many skeletal muscle injuries and diseases have not been resolved. MicroRNA-206 （miR-206） is a skeletal muscle-specific microRNA, which plays an important role in skeletal muscle development and regeneration. OBJECTIVE：To analyze the research status of miR-206 in skeletal muscle injuries and diseases. METHODS：A computer-based search of PubMed was performed for articles about microRNA-206 in skeletal muscle injuries and diseases published from 1992 to 2014 using the keywords of“miR-206, skeletal muscle”. Final y, 57 articles were included in result analysis. RESULTS AND CONCLUSION：miR-206 can regulate neuromuscular junction recovery after nerve muscle injury. Studies have shown that to control miR-206 levels may be a new method for the treatment of amyotrophic lateral sclerosis and other muscle diseases. miR-206 can promote the differentiation of satel ite cel s in cel culture, and the lack of miR-206 can delay the differentiation of satel ite cel s. miR-206 is also found to promote the regeneration of skeletal muscle. After long-term exercise, the miR-206 level shows an adaptive decrease, but if the exercise is stopped for some time, the miR-206 level can return to its original level. Its mechanism remains to be studied.