中文摘要：

Consider the design problem for estimation and extrapolation in approximately lin- ear regression models with possible misspecification. The design space is a discrete set consisting of finitely many points, and the model bias comes from a reproducing kernel Hilbert space. Two different design criteria are proposed by applying the minimax approach for estimating the pa- rameters of the regression response and extrapolating the regression response to points outside of the design space. A simulated annealing algorithm is applied to construct the minimax designs. These minimax designs are compared with the classical D-optimal designs and all-bias extrap- olation designs. Numerical results indicate that the simulated annealing algorithm is feasible and the minimax designs are robust against bias caused by model misspecification.

英文摘要：

Consider the design problem for estimation and extrapolation in approximately linear regression models with possible misspecification. The design space is a discrete set consisting of finitely many points, and the model bias comes from a reproducing kernel Hilbert space. Two different design criteria are proposed by applying the minimax approach for estimating the parameters of the regression response and extrapolating the regression response to points outside of the design space. A simulated annealing algorithm is applied to construct the minimax designs. These minimax designs are compared with the classical D-optimal designs and all-bias extrapolation designs. Numerical results indicate that the simulated annealing algorithm is feasible and the minimax designs are robust against bias caused by model misspecification.