中文摘要：

触发受体的激活面对微生物引起的部件在 myeloid cells-1 (TREM-1 ) 上表示了的背景放大煽动性的反应。学习是在 rats.Methods 成年人男性 Wistar 老鼠在蓄脓症期间调查 TREM-1 小径的调整的效果的礼品的目的受到 Pseudomonas aeruginosa 和葡萄球菌 aureus 的 intrapleural 注射导致的蓄脓症。动物被对待与 LP17 (一个合成 TREM-1 禁止者) ，控制肽，或车辆(正常盐) 。微分房间计数，流动 cytometry 和组织学的检查被执行评估本地煽动性的改变。肿瘤坏死因素的集中--，尽管在肋膜的流出的白血球的每种类型的微分计数没被 LP17 影响，在肋膜的流出和浆液的 interleukin-1 ，和 interleukin-6 被连接酶的 immunosorbent assay.Results 测量，在嗜中性的数字的显著减小在 LP17 被看见由于两个的减小对待老鼠肋膜的流出体积和全部的房间数。LP17 管理在肿瘤坏死因素损害了集中举起 -- ，在肋膜的流出和浆液的 interleukin-l，和 interleukin-6。在 LP17 的幸存率对待老鼠，这被发现在控制 rats.Conclusion 比那高得多由 LP17 的使用的 TREM-1 小径的调整看起来在在在 attenuating 的老鼠的蓄脓症期间有益肋膜、全身的煽动性的回答。

英文摘要：

Background The activation of triggering receptor expressed on myeloid cells-1 （TREM-1） in the presence of microbial components amplifies the inflammatory response. The aim of the present study was to investigate the effect of the modulation of the TREM-1 pathway during empyema in rats. Methods Adult male Wistar rats were subjected to empyema induced by intrapleural injection of Pseudomonas aeruginosa and Staphylococcus aureus. The animals were treated with LP17 （a synthetic TREM-1 inhibitor）, a control peptide, or a vehicle （normal saline）. Differential cell count, flow cytometry and histological examination were performed to evaluate local inflammatory alterations. Concentrations of tumor necrosis factor-a, interleukin-1B, and interleukin-6 in both pleural effusion and serum were measured by enzyme-linked immunosorbent assay. Results Although differential counts of each type of leukocytes in pleural effusion were not affected by LP17, a marked reduction in neutrophil numbers was seen in LP17 treated rats due to the reduction of both pleural effusion volume and total cell numbers. LP17 administration impaired concentration elevation in tumor necrosis factor-（], interleukin-1B, and interleukin-6 in both pleural effusion and serum. It was found that survival rate in LP17 treated rats was much higher than that in control rats. Conclusion The modulation of the TREM-1 pathway by the use of LP17 appears to be beneficial during empyema in rats in attenuating pleural and systemic inflammatory responses.