葡萄胎(hydatidiform mole,HM)是最常见的妊娠滋养细胞疾病,为病理性生殖现象。传统病理学根据大体形态特征将其分为两类:完全性葡萄胎(complete hydatidiform mole,CHM)和部分性葡萄胎(partial hydatidiform mole,PHM)。
Hydatidiform mole is the most common gestational trophoblastic disease and is characterized by gross trophoblastic hyperplasia resulting from abnormal fertilization of the oocyte. It is of great interest to researchers because of its propensity for local invasion and spreading. Using cytogenetic and molecular genetic techniques researchers have performed various studies on hydatidiform mole. There are advances in the understanding of karyotype, DNA ploidy, fertilization types, expression of imprinted genes, the differences between genetic classification and pathologic classification, and the correlation to its invasion and spreading.