中文摘要：

目的 探讨早期早产儿和晚期早产儿合并早发型败血症时的免疫功能特点。方法选择2012年6月至2015年3月广西妇幼保健院新生儿科收治的新生儿,出生24 h内采血进行血常规及免疫功能检查,根据胎龄和感染情况分为早期早产儿败血症组和无感染组、晚期早产儿败血症组和无感染组、足月儿败血症组和无感染组共6组,无感染组按患儿入院先后顺序各纳入100例。检测项目包括血淋巴细胞亚群CD3＋、CD4＋、CD8＋、CD4＋/CD8＋、CD19＋和NK,以及血清Ig G、Ig A、Ig M含量。结果 早期早产儿败血症组NK细胞比例高于无感染组,差异有统计学意义（P〈0.05）;晚期早产儿败血症组CD3＋、CD4＋、CD19＋淋巴细胞比例低于无感染组,NK细胞比例高于无感染组,差异有统计学意义（P〈0.05）;足月儿败血症组CD3＋、CD4＋淋巴细胞比例低于无感染组,NK细胞比例高于无感染组,差异有统计学意义（P〈0.05）。在合并早发型败血症的不同胎龄新生儿中,早期早产儿CD4＋低于晚期早产儿,早期早产儿和晚期早产儿CD3＋、CD4＋、CD8＋、CD19＋、NK均低于足月儿,差异有统计学意义（P〈0.05）;早期早产儿和晚期早产儿Ig G、Ig M低于足月儿。结论 早期早产儿和晚期早产儿的适应性免疫和固有免疫特点相似,且在感染时,晚期早产儿免疫功能并不明显优于早期早产儿。

英文摘要：

Objective early-onset sepsis. Methods To study the immune function of Neonates were assigned into 6 groups early- and late-preterm infants with according to their gestational age and infection ： early-preterm ＋ sepsis group （ E ＋ S ）, non-infected early-preterm group （ E ）, late-preterm ＋ sepsis group（ L ＋ S） and non-infected late-preterm group （ L）, term infants ＋ sepsis group （ T ＋ S ） and non-infected term infants group （T）. The number of non-infected infants was 100 in each group （E, L,T group）. Blood samples were collected within 24 hours after birth and the venous lymphocyte subpopulation （CD3＋ T%, CD4＋ T%, CD8＋ T%, CIM＋/CD8＋, CD19＋% and NK%）and the immunoglobins（ IgG, IgA, IgM） were detected. Results The NK% of E ＋ S group was significantly higher than E group（P 〈0. 05）. The CD3 ＋ T% , CD4 ＋ T% , CD19 ＋ % of L ＋ S group was lower than L group, and the NK% of L ＋ S group was higher than L group （P 〈 0. 05）. The CD3 ＋ T% , CIM ＋ T% of T ＋ S group was lower than T group, and the NK% of T ＋ S group was higher than L group （ P 〈 0.05 ）. The CD4 ＋ T% in E ＋roun was lnwer than T （ P t t/ n＋; ＋ TK＋ cr＋ ＋ To1＋CD19 ＋% and NK% of the two preterm groups （E and T groups） were lower than the term infants group （P 〈 0.05）. IgG and IgM of E ＋ S group and L ＋ S group were lower than T ＋ S group. Conclusions The early- and late- preterm neonates have similar adaptive and innate immune function. The immune function of late-preterm infants is no better than early-preterm infants during infection.