中文摘要：

调查 Erzhi 药片的效果的目的(， EZP ) 在在老朽模型老鼠的神经房间 apoptosis 上。老鼠老朽建模的方法被与 thymusectomy 相结合的腹 D 半乳糖注射建立。四十只 SD 老鼠被使随机化进四个组，正常控制组，老朽模型组， EZP 对待组，并且维生素对待组， 10 在每个组。除了那些，老鼠在正常的组被转变为老朽模型。在 D 半乳糖注射的一样的时间，老鼠经由 intragastric 注入与提取的水， EZP 4.32 g/kg，和维生素 E 和 C 0.06 g/kg 日报分别地被对待 6 个星期。主要内脏的索引(作为大脑，睾丸，等等) ， superoxide dismutase (草皮) 的浆液层次活动，和全部的反氧化能力(T-AOC ) 在一个 6 星期的处理以后被测量。同时，服的外皮 neuronal apoptosis 比例和 mitochondrial 膜潜力(MMP ) 被流动 cytometry 检测。显示出的 EZP 和维生素 E 和 C 处理在增加 T-AOC 的睾丸索引和浆液水平，在服的外皮减少 neuronal apoptosis 的百分比，并且提高在变老的老鼠的 MMP 上完成的结果当模特儿。结论 EZP 能禁止服的外皮神经原 apoptosis 并且坚持说在腹 D 半乳糖注射导致的老鼠的衰老的进程的 mitochondrial 函数与 thymusectomy 结合了。它也显示出 antioxidation 效果到一些程度。

英文摘要：

Objective： To investigate the effects of Erzhi Pill （二至丸,,EZP） on nerve cell apoptosis iinn senescence model rats.Methods： The rats model of senescence was established by peritoneal D-galactose injection combined with thymusectomy.Forty SD rats were randomized into four groups,the normal control group,the senescence model group,the EZP treated group,and the vitamins treated group,10 in each group.The rats were made into senescence model except those in the normal group.In the same time of D-galactose injection,the rats were treated respectively with distilled water,EZP 4.32 g/kg,and vitamins E and C 0.06 g/kg daily for 6 weeks via intragastric infusion.The index of main viscera （as brain,testis,etc.）,serum levels of superoxide dismutase （SOD） activity,and total anti-oxidation capacity （T-AOC） were measured after a 6-week treatment.Meanwhile,the cerebral cortex neuronal apoptosis proportion and mitochondrial membrane potential （MMP） were detected by flow cytometry.Results： Both EZP and vitamins E and C treatments showed effects on increasing testis index and serum level of T-AOC,reducing the percentage of neuronal apoptosis in the cerebral cortex,and elevating MMP in the aging rats model.Conclusions： EZP could inhibit the cerebral cortex neuron apoptosis and maintain the mitochondrial function in the senescent process of rats induced by peritoneal D-galactose injection combined with thymusectomy.It also shows antioxidation effect to some extents.