中文摘要：

目的通过对外周血和肠道组织CD3＋CD4＋T淋巴细胞整合素α4β7表达率的检测,从分子水平为肠道作为HIV感染的主要部位提供依据。方法采用流式细胞仪对外周血和肠道组织中CD3＋CD4＋T淋巴细胞整合素α4β7表达情况进行分析,并对数据进行统计学处理。结果外周血CD3＋CD4＋T淋巴细胞整合素α4β7表达率为（30.2±5.1）%,肠道组织CD3＋CD4＋T淋巴细胞整合素α4β7表达率为（45.2±6.2）%,差异有统计学意义（P〈0.01）。结论整合素α4β7受体使CD3＋CD4＋T淋巴细胞向肠相关淋巴组织归巢,肠道组织CD3＋CD4＋T淋巴细胞整合素α4β7表达率高于外周血。肠道CD3＋CD4＋T淋巴细胞高表达于整合素α4β7,使肠道作为HIV感染的主要部位成为可能。

英文摘要：

[Objective] To provide evidence of molecular level of intestine as major site of HIV infection, we detected α4β7^＋ CD3^＋ CD4^＋ T lymphocytes expression rate in peripheral blood and intestinal tissue. [Methods] The expression of integfin α4β7^＋, CD3^＋ and CD4^＋ in T lymphocytes were tested by flow cytometry, hen data were analyzed statistically. [ Results] The expression rate of α4β7 CD3^＋ CD4^＋ T lymphocytes was （30.2 ±5.1）% in peripheral blood and （45.2 ±6,2）% in intestinal tissue respectively, it was significantly different between peripheral blood and intestinal tissue （P〈0.01）. [Conclusion] Integrin α4β7 makes CD3^＋ CD4^＋ T lymphocytes to the gut-associated lymphoid tissue, the expression rate ofα4β7^＋ CD3^＋ CD4^＋ T lymphocytes is higher in intestinal tissue than in peripheral blood. The high expression of integrin α4β7 in CD3^＋ CD4^＋ T lymphocytes makes intestinal tissue become maior site of HIV infection possibly.