中文摘要：

目的分析儿童青少年期肥胖与成年期血糖水平及糖尿病的关系。方法于1987年采用分层整群抽样方法，在北京市朝阳、西城及海淀区选择6所小学和6所中学，对体检当天6—18岁在校学生（患有先天性心脏病、慢性肾病及肢体残疾者除外）进行体格发育、血压测量及问卷调查，共计3198名。2010年3月至2012年7月进行随访体检及问卷调查，检测血生化指标，共随访到1225名。7~18岁儿童肥胖判定使用中国肥胖问题工作组推荐的7-18岁儿童青少年超重和肥胖标准，6岁儿童肥胖使用美国CDC儿童青少年生长曲线BMI年龄别性别第95百分位值作诊断界值；成年期肥胖采用BMI~28kg／m。诊断。糖尿病诊断：FPG≥7．0mmol／L和／或2hPG≥11．1mmol／L和／或糖化血红蛋白（HbAlc）／〉6．5％和／或服用降糖药和／或使用胰岛素。控制相关变量（年龄、性别、吸烟、饮酒、饮食和睡眠等生活方式），采用多因素非条件logistic回归模型分析儿童期肥胖与成年期糖尿病之间的关联。结果基线肥胖组在成年后血糖诊断糖尿病患病率（16．2％，18／111）高于非肥胖组（5．6％，62／1114）（Z2=18．76，P〈0．001）；糖化血红蛋白诊断糖尿病患病率（18．1％，20／111）也高于非肥胖组（6．9％，77／1114）（Z2=16．66，P〈0．001）。多因素非条件logistic回归分析结果显示，调整控制性别、随访时年龄、吸烟、饮酒、饮食和睡眠因素后，仅儿童肥胖或成年期肥胖不会增加成年期血糖诊断糖尿病发生风险[0R（95％CI）值分别为1．90（0．86—4．19）、1．71（0．50～5．79）]；儿童与成年期均肥胖可增加成年期血糖诊断糖尿病的发生风险[0R（95％CI）：4．50（2．22．9．14）]；调整控制性别、随访时年龄、吸烟、饮酒、饮食和睡眠因素后，仅仅儿童期肥胖或成年期肥胖不会增加成年期糖化血红蛋白诊断糖

英文摘要：

Objective To investigate the correlation between obesity in children and diabetes in adults from a cohort study, and further more to explore the necessity of preventing diabetes by controlling obesity in children. Methods In 1987, 3 198 children and adolescents aged 6-18 were recruited from 6 elementary schools and 6 high schools located in 3 districts （Chaoyang, Haidian, and Xicheng） of Beijing using stratified cluster sampling design. The physical examination process included physical development test, blood pressure measurement, and questionnaire investigation. All children were invited to participate in the study, except for those who had history of congenital heart disease, chronic kidney disease, and limb disability. A total of 1 225 adults were enrolled in a prospective follow-up study from March 2010 to July 2012, anthropometric measures and blood sample were obtained. The obesity was defined by the following criteria： for children aged 6, the age-and the gender-specific 95th percentile of BMI from the US Centre for Disease Control and Prevention Growth charts 2000 as the baseline; for children age 7-18, recommendation from Working Group on Obesity in China （WGOC） as the standard; for adults, BMI≥ 28 kg/m2 as the diagnosis standard. Diabetes was defined based on fasting plasma glucose（FPG）≥7.0 mmol/L or 2 hours postprandial blood glucose （2 h PG）≥11.1 mmol/L or glycosylated hemoglobin （HbAlc）≥6.5% or current using blood glucose-lowering agents or current using insulin. Logistic regression was used to analyze the association obesity in children with diabetes in adults. Results The prevalence of diabetes diagnosed by FPG and 2 h PG in adults who were obese children （16.2%, 18/111） was higher than those who were non-obese children （5.6%, 62/1 114）（Z2=18.76, P〈0.001）. The prevalence of diabetes diagnosed by HbAlc in adults who were obese children（18.1%,20/lll） was higher than those who were non-obese children （6.9%, 77/1 114）（Z2=16.66, P〈O.O01）. With m