中文摘要：

目的埃兹蛋白（Ezrin）和β-连环蛋白（β-catenin）的作用与恶性肿瘤的侵袭转移密切相关,本研究旨在探讨二者在乳腺癌中的临床意义。方法应用免疫组织化学染色法检测145例乳腺癌病理组织中Ezrin和β-catenin蛋白的表达水平,并分析二者相关性及其与乳腺癌临床资料和预后资料的相关性。结果 145例散发性乳腺癌组织中Ezrin阳性表达70例（48.3%）,β-catenin阳性表达82例（56.6%）,二者呈显著负相关（r=-0.267,P=0.001）。乳腺癌组织学分级增高,Ezrin表达水平显著升高（P=0.007）,β-catenin表达水平显著降低（P〈0.001）。发生淋巴结转移的乳腺癌组织Ezrin表达水平显著升高（P=0.027）,β-catenin表达水平显著降低（P=0.011）。Ezrin蛋白表达与乳腺癌患者总体生存期（P=0.004）及无病生存期（P=0.017）缩短显著相关,β-catenin阳性表达则可显著延长患者总体生存期（P〈0.001）及无病生存期（P=0.001）。但多变量Cox回归发现,Ezrin与β-catenin并非影响乳腺癌患者生存期的独立风险因素。结论乳腺癌中Ezrin和β-catenin显著负相关,且在乳腺癌转移、恶化等病程进展及不良预后过程中发挥一定作用,可作为乳腺癌治疗靶点。

英文摘要：

Objective To explore the clinical significance of Ezrin and β-catenin in breast cancer. Methods Immunohistochemical staining method was adopted to detect Ezrin and β-catenin protein expression level in 145 cases of breast cancer tissues,and their correlation with clinical data and prognosis of breast cancer was analyzed. Results Ezrin was expressed in 70 cases（48.3%）,β-catenin was expressed in 82 cases（56.6%）,and there was significantly negative correlation（r = 0.267,P = 0.001）. The higher histologic grade of breast cancer,the higher expression level of Ezrin（P = 0.007）,and the lower expression level of β-catenin（P〈0.001）. Ezrin expression level was increased significantly（P =0.027）,but β-catenin expression level was reduced significantly（P = 0.011）in lymph node positive breast cancer tissue. Ezrin expression was significantly correlated with shorter overall survival（P = 0.004）and disease free survival（P = 0.017）of breast cancer patients,but β-catenin expression was significantly correlated with longer overall survival（P〈0.001）and disease free survival（P = 0.001）of breast cancer patients. However,Ezrin and β-catenin were not the independent risk factors of breast cancer patients as determined by multivariate Cox regression. Conclusion Ezrin was significantly negative correlated with β-catenin in breast cancer. They play a role in the progression and poor prognosis of breast cancer,which can be used as breast cancer treatment targets.