中文摘要：

在AD的发病过程中,多种信号分子的含量异常及分布改变,以及信息传递通路异常,在AD病理改变改变中发挥重要作用;信息传递与信号通路异常是AD发病机制的一个共同途径。第一,AD中,Gia、Gsa蛋白的表达差异是引起腺苷酸环化酶信号系统功能失调;第二,G蛋白的偶联活性的差异是引起腺苷酸环化酶系统信号功能失调的原因：（1）AC与Gia、Gsa蛋白偶联环节出现障碍是AD中AC功能失调的重要原因。（2）G蛋白及其GTP酶活性失常是AD信号转导功能障碍的原因;第三,AD中,G蛋白与受体偶联障碍及受体脱敏是影响G蛋白活性的重要方面;第四,配体激活G蛋白偶联受体的能力损害也是AD中AC功能失调的重要原因;最后,腺苷酸环化酶信号系统功能失调是导致AD病理改变的原因。AD中,G蛋白介导腺苷酸环化酶信号系统功能失调对AD的防治策略有重要启示作用。

英文摘要：

In AD, both the abnormal content and the change of distribution of many kinds of signaling molecules and the ab- normal signal pathways play very important roles in Alzheimer＇ s disease pathological change, and the abnomlal information trans- fer and signal pathways are common channel in Alzheimer＇ s disease pathogenesis. Firstly, the difference of expressed content in Gso~ and GioL protein is the important cause of functional disorder of adenylate cyclase signal system. Secondly, the difference of G protein coupled activity can bring about the functional disorder of adenylate cyclase signal system. （ 1 ） The coupled disorder be- tween Gsct, Gict protein and adenylate cyclase can cause functional disorder of adenylate cyclase in AD. （2） The disorder of GT- Pase activity which can hydrolyses Got-GTP into Ga-GDP is the important cause of signal transdnction dysfunction. Thirdly ,the re- ceptors coupled G protein activity disorder and receptor desensitization are the important aspects of affecting G protein activity. Fourthly, ability impairment of ligands activating G-protein-coupled receptor can also bring about functional disorder of adenylate cyclase. Finally, the disorder of adenylate cyclase signaling can also cause Alzheimer＇ s disease pathological change. The disorder of adenylate cyclase signaling mediated by G protein has an important evocation to prevent and treat Alzheimer＇ s disease.