中文摘要：

目的探讨PNPLA3基因rs 738409（C—G）多态性与青岛地区汉族人群慢性乙型肝炎的相关性。方法收集185例慢性乙型肝炎（CHB）患者和164名正常人的血液标本，采用多聚酶链反应及DNA测序法分析PNPLA3基因型。计数资料比较进行爿。检验，计量资料进行t检验，非条件logistic回归模型计算比值比（OR）及其95％可信区间（CI）。结果CHB组rs738409G等位基因占31．9％，正常对照组为21．90%,两组等位基因频率差异有统计学意义（P〈0．05）；G等位基因携带者患CHB的风险是C等位基因的1．67倍（OR=1．67，95％CI为1．18～2．34，P=0．003）。经混杂因素校正后，logistic回归模型分析结果显示，与CC纯合子携带者相比，携带危险等位基因G的GG＋AG基因型增加CHB的发生风险，OR=1．76，95％CI为1．14～2．71。结论在青岛地区汉族人群中，PNPLA3基因rs738409G等位基因者患CHB的风险性增加。

英文摘要：

Objective To investigate the association between the PNPLA3 rs738409 polymorphism and chronic hepatitis B （CHB） in a Han Chinese population residing in Qingdao. Methods Peripheral blood samples were collected from 185 CHB patients and 164 healthy controls and subjected to polymerase chain reaction （PCR） and DNA sequencing to determine the PNPLA3 genotypes. The relative risk of the rs738409 polymorphism for CHB was estimated by calculating the odds ratio （OR） and 95% confidence interval. Results The rs738409 G allele frequency was significantly different between the CHB and control groups （31.9% vs. 21.9% respectively, P 〈 0.05）. Compared to he rs738409 C allele, the G allele was associated with an increased risk of developing CHB （OR = 1.67, 95% CI： 1.18 - 2.34, P = 0.003）. Logistic regression model analysis, with adjustment for confounding factors, indicated that carriers of the PNPLA3 rs738409 GG ＋ GC genotype had increased risk of CHB than carriers of the CC genotype （OR = 1.76, 95% CI： 1.14 - 2.71,P = 0.011）. Conclusion Oin~dao Han Chinese who are carriers of the rs738409 G allele are at increased risk of CHB.