中文摘要：

目的回顾性研究围术期高浓度吸氧对预防手术部位感染（Surgical site infection,SSI）的作用,以降低SSI的风险。方法通过Medline、EMbase、Pubmed、中国期刊网、万方数据库等数据库查阅文献,收集1982年1月-2015年2月国内外公开发表的有关围术期高浓度吸氧与SSI关系的临床随机对照双盲研究资料,共有970例患者入选,随机分为高氧组487例和对照组483例,应用STATA 12.0软件进行统计分析,应用固定效应模型进行计算。结果文献检索结果最终纳入5篇研究,患者发生SSI感染率高氧组为9.86%、对照组为16.77%;异质性检验（χ^2=2.07,P=0.723）结果显示无异质性存在,且I2=0.0;亚组分析结果均显示,高浓度吸氧是SSI的保护性因素,高浓度吸氧组与对照组率差RD=-0.07（95%CI：-0.11--0.03,P=0.001）。结论该研究荟萃分析发现,围术期高浓度吸氧可以显著降低SSI发生率,鉴于纳入样本量限制,仍需进一步大样本量的临床研究探讨。

英文摘要：

OBJECTIVE To retrospectively study the effect of the perioperative high‐concentration supplemental oxygen therapy on prevention of surgical site infections （SSI） so as to reduce the risk of SSI .METHODS The databases such as Medline ,EMbase ,Pubmed ,Chinese journal net ,and Wanfang database were retrieved for relevant literatures ,the clinical randomized controlled double‐blind studies with respect to the association between the perioperative high‐concentration supplemental oxygen therapy and SSI ,which were issued at home or abroad from Jan 1982 to Feb 2015 ,were collected ;a total of 970 patients were included and randomly divided into the high oxygen group with 487 cases and the control group with 483 group;the statistical analysis was performed with the use of State 12 .0 software ,and the fixed effects model was employed to calculate .RESULTS Totally 5 pieces of researches were included according to the retrieval results .The incidence of SSI was 9 .86% in the high oxygen group ,16 .77% in the control group .The results of heterogeneity test （ χ^2 =2 .07 ,P=0 .723） revealed that the heterogeneity did not exist ,with the I2 of 0 .0 .The results of subgroup analysis showed that the high‐concentration supplemental oxygen therapy was the protective factor of SSI ,and the rate difference （RD） between the high oxygen group and the control group was -0 .07（95% CI：-0 .11- -0 .03 ,P=0 .001） .CONCLUSION The meta‐analysis showed that the perioperative high‐concentration supplemental oxygen therapy can significantly reduce the incidence of SSI .Given the limitation of size of the enrolled samples ,the large size of samples remained to be collected for further clinical study .