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中文摘要：
近年来，随着成千上万个长链非编码RNAs（ long non-coding RNAs， lncRNAs）的发现，人类对基因组以及转录组的认识发生了巨大变化。 lncRNAs在转录、转录后修饰以及表观遗传学水平发挥重要调控作用，广泛参与各种生理和疾病过程。本文旨在归纳与各种肿瘤相关的lncRNAs，介绍目前常用的lncRNAs检测方法，评价其作为生物标志物在临床中的应用价值。（中华检验医学杂志，2015，38：424-427）
英文摘要：
In recent years, the discovery of thousands of long non-coding RNAs （ lncRNAs） has certainly changed human′s view of the complexity of mammalian genomes and transcriptome, as they play an important role in the regulation of transcription, post-transcription as well as epigenetic level, widely involved in various physiological process and diseases.Here this review summarized the lncRNAs associated with cancers, discussed the established methods used to detect and quantify lncRNAs, and evaluated the clinical application of lncRNAs as biomarker.
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