中文摘要：

过氧化物酶体增殖剂活化受体γ（PPARγ）是一个由配体激活的核转录因子，属于核激素受体（nuclear hormone receptor）超家族。它与脂肪形成、免疫应答以及脂质和糖类代谢等生理过程极其相关。尽管PPARγ的合成激动剂已广泛应用于胰岛素致敏剂，但是PPARγ的天然激动剂的鉴定一直不是很清楚，目前，PPARγ的天然激动剂主要有氧化的脂肪酸和硝基脂肪酸，包括9-羟十八碳二烯醇（9-HODE），13-羟十八碳二烯醇（13-HODE），5-脱氧前列腺素J2，油酸和亚油酸的硝基衍生物（分别为OA-NO2和LNO2）等．本文综述了近年的PPARγ的天然激动剂的研究进展。

英文摘要：

The peroxisome proliferator-activated receptor-γ （PPARγ）, a ligand-activated transcription factor, belongs to the nuclear hormone receptor superfamily. It has important roles in adipogenesis and immune response as well as in both lipid and carbohydrate metabolism. Although synthetic agonists for PPARγ are widely used as insulin sensitizers, the identity of natural agonists for PPARγ is still unclear. At present, the natural agonists of PPARγ mainly include oxidized and nitrated fatty acids, such as 9-hydroxyoctadecadienoic acid （9-HODE）, 13-hydroxyoctadecadienoic acid （13-HODE）, and 15-deoxy-△ 12, 14-prostaglandin J2, OA- NO2 and LNO2. This article reviewed the recent achievements of natural agonists ofPPARγ .