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中文摘要：
盐酸氯丙嗪和盐酸异丙嗪在适当的硫酸介质中均能被硫酸铈铵快速氧化成红色化合物，该化合物又逐步被氧化成无色物质，两种药物的动力学过程的差异较小，动力学曲线相似。采集10～180s动力学光谱数据，用主成分回归法（PCR）和偏最小二乘法（PLS）处理所测得的光谱动力学数据，建立了化学计量学速差动力学光度法同时测定该两种药物的新方法。盐酸氯丙嗪和盐酸异丙嗪的线性范围分别为8．3～66．7mg·L^-1和3．3～26．7mg·L^-1，检出限分别为2．32mg·L^-1和0．95mg·L^-1。该法用于药物针剂和片剂的测定，结果良好。
英文摘要：
Chlorpromazine hydroehloride and promethazine hydroehloride were oxidized lastly resulting in red intermediate produet, which was then gradually changed into a colorless product by ammonium eerous sulfate in appropriate acidic medium. The ehernometrie multivariate calibration methods, sueh as partial least squares （PL,S） and prineipal components regression （PCR） were applied to the resolution of the kinetic curves to determine these two compounds. The linear ranges are 8. 3-66. 7 mg·L^-1 and 3. 3-26. 7 mg·L^-1 for ehlorpromazine and promethazine, respectively. The limits of detections are 2. 32 and 0. 95 mg·L^-1 for these two compounds, respectively. This method was successfully applied to the analysis of pharmaceutical samples with satisfied results.
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