中文摘要：

HH（hedgehog）信号通路轴由：hedgehoge配体（Shh、Ihh和Dhh）、Patch和Smo两个膜蛋白形成复合物以及下游锌指核转录因子Gli组成，HH信号通路中锌指核转录因子Gli家族以Gli1为主导并起到决定性作用。上皮-间充质转化与包括口腔鳞状细胞癌在内的多种肿瘤的侵袭和转移密切相关，关于口腔鳞状细胞癌与Shh/Gli1信号轴的作用研究报道较少见，现就口腔鳞状细胞癌发生上皮-间充质转化与Gli1的相关性研究进展作一综述。

英文摘要：

HH(hedgehog)signal pathway consists the hedgehoge ligand(Shh、Ihh and Dhh),the Patch and Smo membrane protein complex and Zinc finger transcription factor Gli(Gli1,Gli2,Gli3).In HH(hedgehog)signaling pathway,Gli1not only plays a dominant and decisive role in the zinc finger transcription factor Gli(Glioma?associated oncogene homolog)family,but also includes epithelial?mesenchymal transition(EMT)and oral squamous cell carcinoma,tumor invasion and metastasis.The research on oral squamous cell carcinoma and Shh/Gli1signal axis is rare.In this paper,the squamous cell carcinoma of oral epithelial mesenchymal transformation and correlation study of quality Gli1is reviewed.