Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system
- 分类：O614.121[理学—无机化学;理学—化学] U231.7[交通运输工程—道路与铁道工程]
- 作者机构：[1]National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, [2]Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, [3]University of Chinese Academy of Sciences, Beijing 100049, China
- 相关基金：We acknowledge the staff at the BL17U and BL18U beamline of the SSRF in China and at the BL-17A beamline of the Photon Factory in Japan for technical assistance during data collection. We thank Y. Y. Chen, Z. W. Yang and B. X. Zhou for help in performing the BIAcore and ITC assays. We also thank Prof. Y. Li （School of Life Sciences, Peking University）, L. Jin （School of Life Sciences, Peking University） and Y. Wu （Institute of Microbiology, Chinese Academy of Sciences） for help in performing the MST experiments. This work was supported by grants from the National Natural Science Foun- dation of China （Grant Nos. 31570768 and 91419308） and the Strategic Priority Research Program （XDB08010301）.
关键词：
信号系统, 晶体结构, 监管机制, 铜绿假单胞菌, L-色氨酸, 抗生素耐药性, 结构紧凑, 化学计量学, the YfiBNR system, c-di-GMP, Vitamin B6,L-Trp, peptidoglycan layer, bioflim formation
中文摘要：
Correspondence： fanz@moon.ibp.ac.cn
Correspondence： tjiang@ibp.ac.cn
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