组蛋白伴侣能够协助组蛋白参与染色质的解凝和组装,从而调控基因的表达,对动植物的配子发生、受精、胚胎发育以及生长、衰老等发育过程都具有重要作用。文章主要对目前研究较多的组蛋白伴侣-核质蛋白、CAF-1、HIRA、ASF1/CIA及NAP1在发育过程中的相关功能作一综述。
Histone chaperones may participate the decondensation and assembly of chromatins, thus regulate gene expression. They play important roles in almost all developmental processes, such as gametogenesis, fertilization, embryogenesis, growth and senescence. In this review, we used well studied examples to illustrate various functions of historic chaperones during developmental processes. Focus is given to nucleoplasmin, CAF-l, HIRA, ASF 1/CIA, and NAP 1.