中文摘要：

采用HPLC-ESI-Q-TOF和MALDI—TOF质谱技术分析儿茶素组成与结构，发现儿茶素中的表没食子儿茶素没食子酸酯（EGCG）具有多聚体特性。有机化学法合成EGCG-Ge^4＋化合物，并经HPLC进一步分离纯化。红外光谱和质谱技术分析并证实EGCG不仅能形成多聚体，而且还能络合金属锗（包括其他金属离子），成为EGCG—Ge^4＋和EGCG-Ge^4＋多聚体。EGCG-Ge^4＋抑制肺癌细胞生长速率明显高于EGCG，其提高幅度约为30％～40％左右。　

英文摘要：

The catachin mainly consists of （ -）-epigallocatechin （EGC）, （ -）-epicate- chin （EC）, （-） epigallocatechin-3-gallate （EGCG）, and （ -）-epicatechin-3-gallate （ECG）. Using a combined method of high performance liquid chromatography-electrospray ionization-Q-time of flight （HPLC-ESI-Q-TOF） mass spectrometry （MS） , polymer compounds of EGCG in the catachin can be separated and analyed the same results were further approved by matrix assisted laser desorption ionization （MALDI）-TOF MS. The EGCG- Ge^4＋ compounds synthesized by normal organic synthesis were further purified by a rapid reversed phase-HPLC for studying inhibition growth rate of the lung cancer cells. During the analytical process of EGCG- Ge^4＋ molecular structures with infrared spectrometry and MALDI-TOF MS, it was found that EGCG not only had polymer characteristics, but also bound to the metal Ge4＋ （or other heavy metal ions, M^2＋） for forming EGCG-Ge^4＋ （or EGCG-M^2＋ ） and its polymers. The experimental results showed that both EGCG and EGCG- Ge^4＋ could inhibit the growth rate of lung cancer cells, showing the similar rate within the 24 h for cell incubating. However, this inhibition rate with EGCG-Ge^4＋ was much higher than that of EGCG, approximately enhancing 30% - 40% rate for inhibiting growth of lung cancer cells was observed within the incubating time covering from 24 to 72 h. Even so/both compounds cannot inhibit the growth rate of melanoma cells. It suggest that the compound EGCG-Ge^4＋ has potentials for developing new drugs for curing lung cancer.