目的:探讨GM-CSF和其诱导的破骨细胞对成骨细胞生长的影响。方法:采用分组对照、细胞计数等方法进行研究。结果:GM-CSF和其诱导的破骨细胞可以促进成骨细胞生长。结论:GM-CSF和其诱导的破骨细胞促进成骨细胞增殖、分化,可能是通过破骨细胞内GM-CSF介导的信号通路而发挥作用。
Objective: To study the effect of GM-CSF and its inducing osteoclast on proliferation of osteoblast. Methods: Contrast to divide into groups to be adopted and the cell counts, use the analysis of variance to examine, define this relation. Results:GM- CSF and its inducing osteoclast induced proliferation of osteoblast. Condusion:GM-CSF can activate the signal pathway and gene expression in the osteoclast, at the same time, express gene result to proliferation of osteoblast.