中文摘要：

目的 探讨慢性乙型肝炎病毒感染与白细胞介素27 p28基因启动子区-964A/G多态性的关系.方法 采用聚合酶链式反应限制性内切酶长度多态性（PCR-RFLP）技术对168例慢性乙型肝炎感染者和152例健康对照者白细胞介素27 p28启动子区-964A/G多态性进行分析,酶联免疫吸附试验（ELISA）检测白细胞介素27血清学水平.结果 慢性乙肝感染组白细胞介素27 p28启动子区-964位点的AA基因型频率明显高于健康对照组（OR=1.75;95%CI：1.12-2.72;P=0.013）;白细胞介素27水平在慢性乙肝患者显著升高（P＜0.001）.结论 白细胞介素27 p28启动子区-964A/G多态性与慢性乙肝病毒感染感染存在一定的相关性,A等位基因可能是HBV易感的遗传因素.

英文摘要：

Objective To explore the relationship between polymorphisms of Interleukin 27（IL-27） p28 gene in promoter region 964A/G and patients with chronic hepatitis B virus（HBV） infection. Methods IL-27p28 genotypes in promoter region 964 were analyzed among 168 patients with chronic HBV infection and 152 healthy controls by using polymerase chain reaction restriction fragment length polymorphism（PCR RFLP） , serum IL-27 levels were measured by enzyme linked immunosorbent assay （ELISA）. Results AA genotype in patients was much higher than in the healthy control group（OR= 1.75;95%CI： 1.12-2.72;P = 0. 013） ,IL-27 was significantly elevated in patients（P〈0. 001）. Conclusion The results shows that polymorphisms of IL-27p28 gene in promoter region 964 were associated with chronic HBV infeetion,A allele may be genetic factor for HBV infection.