目的制备外消旋药喇叭酸甲酯。方法以廉价易得的1,10-癸二醇为原料,经单苄醚化、溴代、格氏反应、乙酰化、氢解脱苄、Jone’s氧化和甲酯化等7步反应,制得外消旋药喇叭酸甲酯。结果以总收率7.2%合成了目标化合物,并经^1HNMR,^13CNMR和MS确证其结构。结论所用方法成本低廉,反应条件温和,适于外消旋药喇叭酸甲酯的大量合成。
OBJECTIVE To prepare the racemic methyl jalapionate.METHODS The title compound was successfully synthesized by using 1,10- decanediol as the starting material via a seven- steps procedure in an overall yield of 7.2% .RESULTS The structure of title compound was confirmed by ^1HNMR, ^13CNMR and MS. CONCLUSION This method is convenient for work - up, economical and available for large- scale synthesis.