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采用空间分辨漫反射测定胃组织光学特性
  • ISSN号:0258-7025
  • 期刊名称:《中国激光》
  • 时间:0
  • 分类:R318.51[医药卫生—生物医学工程;医药卫生—基础医学]
  • 作者机构:[1]华南师范大学激光生命科学研究所暨激光生命科学教育部重点实验室,广东广州510631, [2]中山大学第一附属医院外科,广东广州510080, [3]中山大学第一附属医院眼科,广东广州510080, [4]广东药学院临床医学系外科,广东广州510224
  • 相关基金:国家自然科学基金面上项目(60378043,30470494),广东省自然科学基金(015012,04010394)和广东省科技计划项目(2004810401011)资助课题.
中文摘要:

研究了人正常胃黏膜及黏膜下层组织对488nm,514.5nm,532nm,630nm和632.8nm的激光的光学特性及其差异,实验采用空间分辨反射光和CCD探测器以及非线性拟合确定组织光学特性。结果表明,人正常胃黏膜及黏膜下层组织对五个波长的激光的吸收系数、约化散射系数、光学穿透深度、漫射系数、漫反射率和漫反射率的位移都是随着激光波长的变化而变化的。其吸收系数的最大值在532nm,其值为0.482mm^-1,最小值在632.8nm,其值为0.224mm^-1,最大差异在532nm和632.8nm之间,其值为115%,最小差异在488nm和532nm之间,其值为1.90%。其约化散射系数的最大值在488nm,其值为5.93mm^-1,最小值在632.8nm,其值为3.87mm^-1,最大差异在488nm和632.8nm之间,其值为53.2%,最小差异在514.5nm和532nm之间,其值为3.25%。其光学穿透深度的最大值在632.8nm,其值为0.612mm,最小值在488nm,其值为0.341mm。其漫射系数的最大值在632.8nm,其值为0.084mm,最小值在488nm,其值为0.055mm。其漫反射率的最大值在630nm,其值为0.356,最小值在532nm,其值为0.271。其△x的最大值在632.8nm,其值为0.153mm,最小值在488nm,其值为0.100mm。可见,人正常胃黏膜/黏膜下层组织对五个波长的激光的光学特性参数存在明显的差异。

英文摘要:

The optical properties and differences for normal human stomach mucosa/submucosa tissues in vitro at 488 nm, 514.5 nm, 532 nm, 630 nm and 632.8 nm wavelengths of laser were determined in this paper. Measurements were performed using a charge coupled device (CCD) detector, and optical properties were assessed from the measurements using the spatially resolved reflectance, and nonlinear fitting of diffusion equation. The results of measurement showed that absorption coefficients, reduced scattering coefficients, optical penetration depths, diffusion constants, diffuse reflectance and shifts of the diffuse reflectance of the tissue samples at five different laser wavelengths vary with a change of laser wavelength. The maximum absorption coefficient for tissue samnles is 0. 482 mm^-1 at 532 nm, and the minimum absorption coefficient is 0. 224 mm^-1 at 632.8 nm; the maximum difference in the absorption coefficients is 115% between 532 nm and 632.8 nm, and the minimum difference is 1.90% between 488 nm and 532 nm. The maximum reduced scattering coefficient for tissue samples is 5.93 mm^-1 at 488 nm, and the minimum reduced scattering coefficient is 3.87 mm^-1 at 632.8 nm; the maximum difference in the reduced scattering coefficients is 53.2% between 488 nm and 632.8 nm, and the minimum difference is 3.25% between 514.5 nm and 532 nm. The maximum optical penetration depth for tissue samples is 0. 612 mm at 632.8 nm, and the minimum optical penetration depth is 0. 341 mm at 488 nm. The maximum diffusion constant for tissue samples is 0. 084 mm at 632.8 nm, and the minimum diffusion constant is 0. 055 mm at 488 nm. The maximum diffuse reflectance for tissue samples is 0. 356 at 630 nm, and the minimum diffuse reflectance is 0. 271 at 532 nm. The maximum shift of the diffuse reflectance of the oblique incidence for tissue samples is 0. 153 mm at 632.8 nm, and the minimum shift of the diffuse reflectance of the oblique incidence is 0. 100 mm at 488 nm. It is obvious that there were distinct differences in the optical pa

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期刊信息
  • 《中国激光》
  • 北大核心期刊(2011版)
  • 主管单位:中国科学院
  • 主办单位:中国光学学会 中国科学院上海光学精密机械研究所
  • 主编:周炳琨
  • 地址:上海市嘉定区清河路390号
  • 邮编:201800
  • 邮箱:cjl@siom.ac.cn
  • 电话:021-69917051
  • 国际标准刊号:ISSN:0258-7025
  • 国内统一刊号:ISSN:31-1339/TN
  • 邮发代号:4-201
  • 获奖情况:
  • 中国自然科学核心期刊,物理学类核心期刊,无线电子学·电信技术类核心期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘(网络版),荷兰文摘与引文数据库,美国工程索引,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:26849