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微小RNA：肿瘤生物学研究的新热点
  • ISSN号：1671-6264
  • 期刊名称：《东南大学学报：医学版》
  • 分类：R730.231[医药卫生—肿瘤;医药卫生—临床医学] Q522.5[生物学—生物化学]
  • 作者机构：[1]南京大学,生命科学学院,医药生物技术国家重点实验室,江苏,南京,210093, [2]南京大学生命科学学院,医药生物技术国家重点实验室,江苏南京210093
  • 相关基金：国家自然科学基金资助课题（31071232,31170751）
作者： 虞峰[1], 陈江宁[2], 张峻峰[1]
关键词： MIRNA, 肿瘤生物学, 基因表达调控, 综述
中文摘要：

微小RNA（microRNA,miRNA）是一类碱基长度为19~24 bp的内源性非编码RNA分子,在生命活动中通过识别mRNA的3′-非翻译区抑制其翻译,广泛调控肿瘤相关蛋白的表达,在肿瘤等疾病的发生与发展中扮演重要角色.随着调控的靶基因的不同,miRNA在肿瘤中分别表现为原癌基因和肿瘤抑制基因的作用.miRNA和靶基因之间的关系有着高度的复杂性,而miRNA自身的加工成熟过程也受到多种因素的影响,是系统生物学和生物信息学重要的潜在应用领域.作者就miRNA等有关与肿瘤分子调控和其在肿瘤组织中差异性表达方面的文献报道作一综述.

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期刊信息
  • 《东南大学学报：医学版》
  • 中国科技核心期刊
  • 主管单位:教育部
  • 主办单位:东南大学
  • 主编：唐萌
  • 地址：南京市鼓楼区丁家桥87号
  • 邮编：210009
  • 邮箱：bjb@pub.seu.edu.cn
  • 电话：025-83272481
  • 国际标准刊号：ISSN：1671-6264
  • 国内统一刊号：ISSN：32-1647/R
  • 邮发代号:28-265
  • 获奖情况:
  • 全国优秀学报,铁道部优秀期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,波兰哥白尼索引,中国中国科技核心期刊,中国北大核心期刊（2014版）
  • 被引量:8241