中文摘要：

微生物间通过群体感应效应进行交流并调控重要基因的转录及表达。目前发现参与这种信息传递最普通的信号分子是N-脂酰高丝氨酸内酯。通过抑制N-脂酰高丝氨酸内酯在群体感应系统中的信号传导，可以阻断病原基因的转录启动，以抑制病原因子的表达和作用，达到抗微生物感染的目的，是一种潜在的防治疾病新途径。

英文摘要：

Quorum-sensing response could control the transcription and expression of key genes in microbial cells by concentration of signals autoinducer, in which N-acyl-homoserine-lactones are the gen- eral and global singals. Signal transmission can be quenched by inhibition of N-acyl-homoserineqactone, leading to breaking the initial of pathogenic genes transcription and the expression of virulence. It is a potential application in protection against microbial disease.