中文摘要：

目的：观察富马酸比索洛尔治疗老年血压伴心功能不全患者的临床疗效。方法：将100例患者随机分为治疗组和对照组,各50例,对照组给予常规治疗,治疗组在常规治疗的基础上加用比索洛尔,疗程8周。观察其治疗前后血压、心率、左室质量指数（LVMI）、室间隔厚度（IVS）、左室后壁厚度（LVWP）、左室舒张末期容量（LVEDV）、左室收缩末期容量（LVESV）、射血分数（EF）和舒张功能指标（E/A）,以及血浆脑钠素（BNP）、血管内皮生长因子（VEGF）和高敏C-反应蛋白（hs-CRP）、肝肾功能等血液生化指标。结果：治疗组患者治疗后收缩压、舒张压及心率均较治疗前明显降低（P〈0.01）,且治疗后的心功能各指标（除NYHA分级IV）均优于治疗前（P〈0.05）,其中LVEDV、LVESV、LVMI、EF和E/A优于对照组（P〈0.05）。治疗组治疗后BNP、VEGF及hs-CRP较治疗前显著降低（P〈0.01）,且治疗组BNP水平显著优于对照组（P〈0.01）。两组患者血常规及肝肾功能检查治疗前后均在正常范围,差异无统计学意义（P〉0.05）。结论：比索洛尔治疗高血压伴心功能不全疗效确切且安全可靠。

英文摘要：

Objective： To observe the clinical effect of bisoprolol in treating elderly patients with hypertension and cardiac insufficiency. Method： 100 patients were enrolled and randomly divided into treatment group（ n = 50） and control group（ n = 50）. The control group received routine treatment,while bisoprolol was added to treatment group for a course of 8 weeks. The blood pressure,heart rate,left ventricular mass index（ LVMI）,interventricular septum thickness（ IVS）,left ventricular posterior wall thickness（ LVWP）,left ventricular end- diastolic volume（ LVEDV）,left ventricular end systolic volume（ LVESV）,ejection fraction（ EF） and diastolic function index（ E / A） before and after the treatment were observed. Blood biochemical indicators including brain natriuretic peptide（ BNP）,vascular endothelial growth factor（ VEGF）,high-sensitivity C-reactive protein（ hc-CRP） and hepatorenal functions were also recorded. Result： The systolic pressure,diastolic pressure and heart rate of the treatment group were obviously lower than those before the treatment（ P 0.01）,and cardiac function indicators（ except for NYHA grading IV） were all better than those before the treatment（ P 0.05）,among which LVEDV,LVESV,LVMI,EF and E / A were superior to those of control group（ P 0.05）. BNP,VEGF and hs-CRP of the treatment group decreased remarkably after the treatment（ P 0.01）,and BNP level of the treatment was superior to that of control group（ P0.01）.The blood routine and hepatorenal function examination of the two groups before and after the treatment all showed normal results,and the difference was no statistical significance（ P 0. 05）. Conclusion：Bisoprolol is effective and safe in treating patients with hypertension and cardiac insufficiency.