中文摘要：

目的：观察糖痹消联合甲钴胺治疗糖尿病周围神经病变（DPN）的临床疗效。方法：将110例DPN患者随机分为对照组和研究组,每组各55例。对照组在糖尿病常规治疗基础上采用甲钴胺片口服,研究组在对照组的基础上口服糖痹消。比较两组临床疗效、治疗前后中医证候评分、感觉神经传导速度（SNCV）、的运动神经传导速度（MNCV）及血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、可溶性细胞间黏附分子-1（s ICAM-1）、内皮素-1（ET-1）水平。结果：治疗前两组中医症候评分、SNCV、MNCV、血清IL-6、TNF-α、s ICAM-1、ET-1水平比较,差异均无统计学意义（P〉0.05）;治疗后研究组中医证候评分低于对照组,差异具有统计学意义（P〈0.05）;SNCV和MNCV、血清IL-6、TNF-α、s ICAM-1、ET-1水平均优于对照组,差异具有统计学意义（P〈0.05）。对照组有效率为74.4%,研究组有效率为90.9%,两组有效率比较,差异具有统计学意义（P〈0.05）。结论：糖痹消方联合甲钴胺治疗DPN疗效显著,安全性好。

英文摘要：

Objective： To observe the clinical curative effect of Tang Bi Xiao（ TBX） in combination with mecobalamin on diabetic peripheral neuropathy（ DPN）. Methods： One hundred patients with DPN were divided into the control group and the research group according to random number table method,with 55 cases in each group. The ones in the control group were given mecobalamin for oral administration based on routine diabetic treatment,while the ones in the research group were added TBX for oral administration based on the treatment of the control group. Then the two groups＇ clinical curative effects,TCM syndrome score before and after the treatment,SNCV,MNCV,IL-6,TNF-α,s ICAM-1 and ET-1 levels were compared. Results： Before the treatment,the differences in two groups＇ TCM syndrome scores,SNCV,serum IL-6,TNF-α,s ICAM-1 and ET-1 level had no statistical significance（ P〉0. 05）. After the treatment,TCM syndrome score of the research group was lower than that of the control group,and the difference between them had statistical significance（ P〈0. 05）; and its SNCV,MNCV,blood IL-6,TNF-α,s ICAM-1 and ET-1levels were all better than those of the control group,and the differences between them had statistical significance（ P〈0. 05）. The effective rate of the control group was,while that of the research group was,and the difference between them had statistical significance（ P〈0. 05）. Conclusion： TBXin combination with mecobalamin has the remarkable clinical curative effect DPN with great safety..