中文摘要：

目的：研究红树林内生真菌Aspergillus sp.085035的次级代谢产物。方法：采用柱色谱和半制备高效液相色谱技术对Aspergillus sp.085035的次级代谢产物进行分离纯化,并利用波谱数据和X-射线单晶衍射等方法鉴定化合物结构;采用MTT法对所得化合物进行细胞毒活性检测。结果：从红树林内生真菌Aspergillus sp.085035的乙酸乙酯粗提物中分离得到9个化合物,分别鉴定为：13R-fumigaclavine C（1）、8＇-O-methylasterric acid（2）、1,2-secotrypacidin（3）、rhizoctonic acid（4）、chaetominine（5）、helvolic acid（6）、trypacidin（7）、emodin-8-methylether（8）和fumitremorgin C（9）。结论：化合物1为新天然产物,化合物1、8为首次从曲霉属中分离得到,所有化合物均为首次从该真菌中分离得到,化合物7对MDA-MB-435细胞株具有细胞毒活性。

英文摘要：

Objective：To study the secondary metabolites of Aspergillus sp.085035 from South China Sea.Methods：The metabolites of Aspergillus sp.085035 were isolated and purified by silica gel column chromatography and semipreparative HPLC,and their structures were elucidated by MS and NMR spectra,and then confirmed by a single-crystal X-ray crystallographic analysis.The cytotoxicity of the compounds was tested by MTT assay.Results：Nine compounds were isolated from the mangrove endophytic fungus Aspergillus sp.085035,and their structures were identified as 13R-fumigaclavine C （1）,8＇-O-methylasterric acid （2）,1,2-seco-trypacidin （3）,rhizoctonic acid （4）,chaetominine （5）,helvolic acid （6）,trypacidin （7）,emodin-8-methylether （8） and fumitremorgin C （9）.Conclusion：Compound 1 is a new natural product,compounds 1,8 are isolated from Aspergillas sp.genus for the first time,all the compounds are isolated from this furgus for the first time.Compound 7 exhibits cytotoxicity against MDA-MB-435 cells.