中文摘要：

肝主疏泄与解剖学之脑和肝脏功能相关,其调畅气机的功能与肝脏调节物质代谢（能量）、流动以及分布有关,肝窦内皮细胞窗孔构成的肝筛结构可能是肝疏布、宣泄气机及精微、毒物的超微结构。慢性肝病如慢性肝炎、肝纤维化和脂肪肝的病机多为肝失疏泄、由气及血、络脉瘀阻,表现为肝窦内皮细胞窗孔数量、结构及功能异常,引起微循环障碍。因此,肝窦内皮功能障碍可能是肝失疏泄之络病的病机关键,是肝主疏泄之络病理论新的假说。

英文摘要：

Liver that dominates dispersion and discharge is mainly attributed to the function of organs such as brain and liver.The dispersion and discharge function have relationship with metabolism,flow and distribution of substance（energy）.The liver sieve that formed from fenestrae of sinusoidal endothelial cell（SEC） is probablely the ultrastructure that operating essential substance and discharging poison and waste.Disfunction of dispersion and discharge of liver that lead to stagnation in liver channel is the pathogenesis of chronic liver disease such as chronic hepatitis,liver fibrosis and fatty liver that menifested as the abnormal of number,structure and function of fenestrae and microcirculation disturbance.So,our hypothesis is that the disfunction of sinusoidal endothelial is the key pathogenesis of collaterals disease from disfunction of dispersion and discharge of liver.