中文摘要：

目的通过半合成法高收率制得紫杉醇。方法在可回收手性配体的催化作用下，通过不对称氨羟化反应一步合成紫杉醇C13侧链，对侧链的羟基和氨基进行保护后生成（4S，5R）-N-苯甲酰基-2-（4’-甲氧基）苯基-4-苯基-1,3-氧氮杂戊环-5-甲酸，进而和7-三乙基硅烷巴卡亭-Ⅲ缩合、去保护得到紫杉醇。结果获得了高光学纯度的紫杉醇C13侧链（化学收率41%，光学纯度99%）和紫杉醇（化学收率39%，光学纯度99%）。结论此方法反应步骤少、操作简单，为紫杉醇的半合成开辟了一条新路线。

英文摘要：

Aim To synthesize paclitaxel by a new economical and practical way. Method The C13 side chain of paclitaxel was synthesized via asymmetric aminohydroxylation of trans-cinnamate, which was catalyzed by a kind of free recoverable and reused chiral ligand and OsO4. Then the OH and NH2 group of the C13 side chain was protected and （ 4 S, 5R）- N-benzoyl-2- （ 4＇-methoxy ） phenyl-4-phenyl-1, 3-oxazolidine-5-carboxylic acid was prepared. Finally, paclitaxel was generated by condensing （4S, 5R ）-N-benzoyl-2-（4＇ -methoxy） phenyl-4-phenyl-1, 3-oxazolidine-5-carboxylic acid with 7-triethylsilyl baccatin-Ⅲ, deprotection and purification. Results The C13 side chain of paclitaxel was obtained with the chemical yield of 41% and ee. of 99 %. Total yield of paclitaxel was 39 %, and ee. was 99 %. Conclusion This method is convenient and practical to produce paclitaxel in large scale.