中文摘要：

目的：探讨左归降糖益肾方对高脂饮食转基因2型糖尿病MKR鼠糖脂代谢及炎症反应的影响。方法：用左归降糖益肾方干预治疗高脂饲料喂养的转基因2型糖尿病MKR鼠,采用电化学法测定空腹血糖浓度,采用全自动生化分析仪检测血脂和超敏C反应蛋白（hs-CRP）,采用酶联接免疫吸附剂测定（ELISA）检测血清胰岛素与肿瘤坏死因子-α（TNF-α）水平。结果：高脂饲料喂养的MKR小鼠空腹血糖高于MKR组,但无统计学意义;血清胰岛素,血总胆固醇（TCHO）,血低密度脂蛋白胆固醇（LDL-C）,血高密度脂蛋白胆固醇（HDL-C）,LDL-C/HDL-C,血清hs-CRP和TNF-α水平高于MKR组（P〈0.01）,而甘油三酯（TG）下降,低于MKR组（P〈0.01）。经左归降糖益肾方或文迪雅干预治疗后,高脂饮食MKR小鼠血糖、血清胰岛素,TG,LDL-C/HDL-C,血清hs-CRP和TNF-α水平显著下降（P〈0.05,P〈0.01）;左归降糖益肾方组TCHO,LDL-C下降（P〈0.05）,HDL-C上升（P〈0.05）,而文迪雅对照组TCHO,LDL-C下降和HDL-C上升无统计学意义。结论：左归降糖益肾方能减轻高脂饮食加重的MKR鼠的胰岛素抵抗,增强外周组织对胰岛素的敏感性,调节高脂饮食MKR鼠糖脂代谢,减少炎症因子的产生。

英文摘要：

Objective： To observe the protective effect of Zuogui Jiangtang Yishen Recipe（ZGJTYS） on regulating glucose-lipid metabolism and inflammatory cytokines in MKR mice with high-fat diet.Method： Intervention of ZGJTYS was executed in MKR mice with high-fat diet.Fasting blood-glucose（FBG）,insulin（INS）,blood-lipid,hs-CRP and TNF-α levels in serum were examined.Result： Compared with MKR mice,FBG level in the mice with high-fat diet elevated（but P 0.05）;INS,total cholesterol（TCHO）,high density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,LDL-C /HDL-C,hs-CRP and TNF-α in the mice with high-fat diet were higher than those in control MKR mice.（P 0.05 or P 0.01）,but TG level reduced（P 0.01）.After intervention of ZGJTYS,FBG,INS,TG,TCHO,LDL-C,LDL-C /HDL-C,hs-CRP,TNF-α in the mice with high-fat diet decreased significantly（P 0.05 or P 0.01）,while HDL-C level significantly increased（P 0.05）.Conclusion： ZGJTYS could significantly improve insulin resistance,regulate glucose-lipid metabolism,and reduce inflammatory cytokines.