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Experimental measurement of the correlation between CT number and heavy ion range

ISSN号：1674-1137
期刊名称：Chinese Physics C
时间：2012.10.10
页码：954-957
分类：TP391.41[自动化与计算机技术—计算机应用技术;自动化与计算机技术—计算机科学与技术] Q691[生物学—生物物理学]
作者机构：[1]InstituteofModernPhysics,ChineseAcademyofSciences,Lanzhou730000,China, [2]KeyLaboratoryofHeavyIonRadiationBiologyandMedicineofChineseAcademyofSciences,Lanzhou730000,China, [3]GraduateUniversityofChineseAcademyofSciences,Beijing100049,China
相关基金：Supported by National Basic Research Program of China （973 Program, 2010CB834203）; Key Project of National Natural Science Foundation of China （10835011）; National Natural Science Foundation of China （10905080, 11075191）; Science and Technology Development Project of Lanzhou City （2008-sr-10, 2009-2-12）
相关项目：减小重离子治癌当中展宽Bragg峰区后沿剂量半影的方法研究

关键词：重离子束, 实验测量, 计算机断层扫描, CT值, 重离子治疗, 校准曲线, 碳离子束, X射线CT, heavy ion therapy, CT number, WEPL, CT-WEPL calibration curve

中文摘要：

For precision delivery of the Bragg peak of a heavy-ion beam to a target volume in ion beam therapy, it is necessary to know the tissue stopping power. A general approach to solve this problem in ion beam therapy is to convert X-ray CT (computed tomography) numbers into water-equivalent path length (WEPL) coefficients using a CT-WEPL calibration curve for all voxels traversed by the beam. This work aims at establishing a CT-WEPL coefficient calibration curve for the heavy ion therapy project at IMP, so as to compute the range of carbon ion beams in tissues easily according to the patient CT data. Several tissueequivalent materials were applied to measure their WEPL coefficients using a high-energy carbon ion beam in this work. A CT-WEPL calibration curve was obtained through fitting the measured data, which can be used directly for dose optimization and facilitates the design of patient treatment plans significantly at IMP.

英文摘要：

For precision delivery of the Bragg peak of a heavy-ion beam to a target volume in ion beam therapy, it is necessary to know the tissue stopping power. A general approach to solve this problem in ion beam therapy is to convert X-ray CT （computed tomography） numbers into water-equivalent path length （WEPL） coefficients using a CT-WEPL calibration curve for all voxels traversed by the beam. This work aims at establishing a CT-WEPL coefficient calibration curve for the heavy ion therapy project at IMP, so as to compute the range of carbon ion beams in tissues easily according to the patient CT data. Several tissueequivalent materials were applied to measure their WEPL coefficients using a high-energy carbon ion beam in this work. A CT-WEPL calibration curve was obtained through fitting the measured data, which can be used directly for dose optimization and facilitates the design of patient treatment plans significantly at IMP.

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