中文摘要：

肥胖与胰岛素抵抗、脂代谢紊乱、高血压及糖耐量降低是代谢综合征的主要特点。过氧化物酶体增殖物活化受体（PPAR）δ是新近发现的PPAR家族的新成员，存在多种配体。激活PPARδ可增强脂肪及肌肉组织中的脂肪酸氧化和能量偶联，抑制巨噬细胞内的炎症反应，同时具有改善血脂和胰岛素抵抗的作用。这些功能提示PPA鼢可用于控制体重、增加胰岛素敏感性，缓减冠心病症状，可能是极具潜力的代谢综合征治疗的新靶点。

英文摘要：

Obesity, insulin resistance, dyslipidemia, hypertension and glucose intolerance are some major characteristics of metabolic syndrome. PPARδ is a novel discovered isoform of PPARs family with abundant ligands. Activation of PPARδ can enhance fatty acid oxidation and energy uncoupling in adipose tissue and muscle, suppress macrophage-defived inflammation, and improve both hypertfiglycefidemia and insulin resistance. These physio-logical functions of PPARδ imply that it may be a thempeutic target for the treatment of metabolic syndrome via controlling body weight, improving insulin sensitivity, and ameliorating the symptom of atherosclerosis.