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Human bocavirus infections are common in Beijing population indicated by sero-antibody prevalence analysis
  • ISSN号:0366-6999
  • 期刊名称:《中华医学杂志:英文版》
  • 时间:0
  • 分类:R978.1[医药卫生—药品;医药卫生—药学] R511[医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]Graduate School, Peking Union Medical College, Beijing 100730, China, [2]Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China, [3]Influenza and Respiratory Viruses Section, National Microbiology Laboratory, Public Health Agency of Canada, Canada
  • 相关基金:This study was supported by a grant from the National Natural Science Foundation of China (No. 30872153).
中文摘要:

背景人的 bocavirus (HBoV ) 是原来与呼吸感染在孩子的呼吸分泌物被检测的最新识别的人的 parvovirus。试图由在浆液标本的二批在不同时期收集了的北京 population.Methods 对 HBoV 揭示浆液抗体的流行了解 HBoV 感染的重要性的这研究被从在1996年4月期间收集的 677 个浆液标本的作为 antigen.Results 的用 recombinant VP2 的对 HBoV 的为特定的 IgG 的西方的弄污测试到1997年3月,(59.1%) 400 是积极的并且为 141 个浆液标本的另一批的积极的率在8月收集了的抗体, 200 为在 1996-1997 期间收集到那些的浆液标本的sero流行侧面的比较在 2005 收集了显示为标本的积极的率在 2005 收集了的抗体比在 1996-1997 .Conclusions 期间收集的相应年龄组的高数据建议那 HBoV 在北京人口一直在传播为至少超过 10 孩子的年,和大多数到 7 年的年龄暴露于 HBoV 。在浆液标本显示出的积极的率在 2005 收集了的更高的 HBoV 抗体建议由 HBoV 的感染在最近的年里在北京人口被增加了。

英文摘要:

Background Human bocavirus (HBoV) is a newly identified human parvovirus that was originally detected in the respiratory secretions of children with respiratory infections. This study aimed to learn about the importance of HBoV infections by revealing the prevalence of serum antibodies against HBoV in Beijing population. Methods Two batches of serum specimens collected in different periods were tested by Western blotting for specific IgG against HBoV using recombinant VP2 as antigen. Results Out of 677 serum specimens collected during April 1996 to March 1997, 400 (59.1%) were positive and antibody positive rate for another batch of 141 serum specimens collected in August, 2005 from adults aged from 20 years to over 60 years was 78.7% (111/141). Comparison of the sero-prevalence profiles for serum specimens collected during 1996-1997 to those collected in 2005 indicated that the antibody positive rate for specimens collected in 2005 was higher than that of the corresponding age groups collected during 1996-1997. Conclusions The data suggest that HBoV has been circulating in Beijing population for at least over 10 years, and most of children had been exposed to HBoV by age of 7 years. Higher HBoV antibody positive rate shown in the serum specimens collected in 2005 suggested that infections by HBoV have been increased in Beijing population in recent years.

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期刊信息
  • 《中华医学杂志:英文版》
  • 中国科技核心期刊
  • 主管单位:中国科协
  • 主办单位:中华医学会
  • 主编:
  • 地址:北京东四西大街四十二号
  • 邮编:100710
  • 邮箱:cmj@cma.org.cn
  • 电话:010-85158321
  • 国际标准刊号:ISSN:0366-6999
  • 国内统一刊号:ISSN:11-2154/R
  • 邮发代号:2-920
  • 获奖情况:
  • 1997、1998、1999年获中国科协优秀科技期刊择优资...,1992、1997年连续两年荣获全国优秀科技期刊和中国...,中国期刊方阵双高期刊
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  • 被引量:3319