中文摘要：

长链非编码RNA（long noncoding RNA,lnc RNA）是一组在转录、转录后和表观遗传水平发挥作用的调控序列,其在中枢神经系统中特异性高表达,对中枢神经系统发育和疾病发展具有重要调控作用。缺血性脑卒中诱导脑内大量lnc RNA表达改变,提示lnc RNA与缺血性脑卒中复杂的病理过程有关,这将有利于全面认识缺血性脑卒中的病理机制及脑缺血损伤后的分子调控网络,并提供新的治疗方向。尽管有少数研究报道lnc RNA在缺血性心脏病中的作用,但目前对于其在缺血性脑卒中病理发展中的作用知之甚少。综述目前已知的lnc RNA在脑缺血再灌注损伤、细胞凋亡与抗凋亡及损伤后神经再生与修复中的作用,并提出了未来可能的lnc RNA在缺血性脑卒中损伤与修复中的研究方向。

英文摘要：

Long noncoding RNAs （lncRNAs） are transcribed from a large class of genes in human genome, and are emerging as key regulators of multiple biological processes at transcriptional, post-transcriptional and epigenetic levels. Many lncRNAs are highly expressed in the central nervous system （CNS） in a specific manner, suggesting that they might play important roles in CNS development and diseases. Cerebral ischemic stroke significantly alters lncRNA expression profiles in CNS, indicating that the disregulation of lncRNAs may contribute to the complex pathological process after ischemic stroke. Taking further insights into the function of lneRNAs is helpful for us to construct molecular regulatory networks and to open a new field of therapeutic targets in ischemic stroke. Although there are few reports about lncRNAs in ischemic heart dis- eases, much less is currently known about lncRNAs in ischemic stroke. Current progresses are summarized on the role of lncRNAs in ischemia-reperfusion injury, apoptosis/anti-apoptosis, neurorestoration and neurogenesis. Finally, potential research directions of lncRNAs and ischemic stroke in the future are proposed.