氨基的拥有的新多功能的 mPEG-b-PAA-grafted chitosan 共聚物和 carboxyl 组, mPEG-b-PAA-g-CHI (化合物 6 ),在基因/药交货为潜在的应用被设计并且由可逆增加破碎链转移(木排)的方法综合了丙烯酸的酸( AA )和可被细菌破坏的 chitosan (迟)的 grafting 反应的聚合衍生物。产生混合物的反应和描述的结束被 1H NMR, FTIR 和胶化浸透 chtomatography (GPC ) 研究表明。结果证明到在共聚物(化合物 6 ) 的 carboxyl 组的氨基的组的臼齿的比率是 0.41:0.59。
A new multifunctional mPEG-b-PAA-grafted chitosan copolymer possessing amino and carboxyl groups, mPEG-b-PAA-g-CHI (compound 6), was designed for a potential application in gene/drug delivery and synthesized by the methods of reversible addition-fragmentation chain transfer (RAFT) polymerization of acrylic acid (AA) and grafting reaction of a biodegradable chitosan (CHI) derivative. Completion of the reactions and characterization of the resulting compounds were demonstrated by ^1H NMR, FTIR and gel permeation chtomatography (GPC) studies. The results show that the molar ratio of amino groups to carboxyl groups in the copolymer (compound 6) is 0.41:0.59.