中文摘要：

cis-nitenpyram 类似物(2a2p ) 的一个新奇系列被设计并且由介绍 1,4-dihydropyridine 准备了，与他们 X 光检查衍射证实的 cis 配置。初步的生物鉴定证明大多数混合物对蚜虫属 medicagini 在 20 mg/L 展出了好杀虫的活动，并且类似物 2a 和 2d 负担得起最好的活动，并且他们俩在 4 mg/L 有 100% 死亡。另外，分子的停靠研究也被执行为 ligand 受体建筑群建模，并且结果解释了在 vitro 观察的结构活动关系，它可以为新杀虫药剂的未来设计提供一些有用信息。

英文摘要：

A novel series of cb-nitenpyram analogues （2a--2p） were designed and prepared by introducing the 1,4-dihydropyridine, with their eis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most compounds exhibited good insecticidal activities at 20 mg/L against Aphis medicagini, and analogues 2a and 2d aflbrded the best activity, and both of them had 100% mortality at 4 mg/L. In addition, molecular docking studies were also performed to model the ligand-receptor complexes, and the results explained the structure-activity relationships observed in vitro, which may provide some useful information for future design of new insecticides.