中文摘要：

Bromodomains是包含110个氨基酸的蛋白质功能结构域,可选择性识别组蛋白末端乙酰赖氨酸位点,参与表观遗传基因的读取和调控,影响一些疾病的发生。而基于Bromodomains靶体的小分子抑制剂的合成与应用,成为药物化学领域的研究热点。因此,对近三年该领域的合成进展进行归纳和总结,可为抗癌药物的发现提供研究思路。

英文摘要：

Bromodomains are specific functional protein domains containing more than 100 amino acids,which could selectively recognize acetylated lysine at the end of histones. In the meanwhile,Bromodomains are involved in the reading and regulating epigenetic gene resulting in some diseases. Therefore,the synthesis and application of small molecule inhibitor based on Bromodomains,have become a hot topic in the pharmaceutical chemistry. Herein,the current progress has been summarized in near three years,which can provide ideas and strategies for anti-cancer drug discovery.