中文摘要：

观察DHEA（17aa-D-高炔雌二醇-3-乙酯）联合137CsY射线辐照对ECl09移植小鼠肿瘤的抑制作用及放疗后对荷瘤小鼠造血系统的防护作用。将接种食管癌细胞系ECl09的裸鼠按照处理方式的不同分为对照组、单照组、DHEA组和DHEA联合辐照组，给药组连续给药9d，12d后分别检测肿瘤抑制率、外周血细胞数、骨髓有核细胞数等指标。结果表明，DHEA组抑瘤率明显高于对照组，DHEA联合辐照组的瘤重分别低于单照组和对照组，具有统计学差异（p〈0．01）。DHEA联合辐照组的红细胞、血红蛋白均高于对照组及单照组，差异有统计学意义（p〈0．05）。提示DHEA联合1，射线辐照对食管癌移植小鼠肿瘤具有显著的协同抗瘤效果，DHEA对辐照后荷瘤小鼠造血系统具有一定的防护作用。

英文摘要：

The antitumor effect of 17a-D-homo ethynyclestradiol-3-accetate （DHEA） combined with Y-rays and protective effect of DHEA on hematopoietic fimction in tumor-bearing mice was studied in this paper. The EC109-inoculated nude mice were divided into four treatment groups as DHEA, DHEA combined with Y-rays,Y-rays only, and control group. The groups with DHEA were continuously delivered drugs for 9 days, and the inhibition rate of tumor, blood count, and nucleated cell in bone marrow were examined 12 days later. The results showed that inhi- bition rate of tumor in DHEA group increased compared with that of control group; the tumor weight of the irradiated group was lighter than that of DHEA combined with Y-rays group （p〈0.01）. In DHEA combined with Y-rays group, RBC and Hb were significantly increased compared with that in radiation group. DHEA and y-rays have synergic ef- fect in inhibiting esophageal cancer growth and DHEA can protect hematopoietic function in radiation-injured mice.