欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
以自制的琥珀酰化壳聚糖（SUCS）和羟甲基-5氟尿嘧啶（5-FuOH）为原料，制备了壳聚糖偶联载药体（SUCS-5-FuOH）。傅里叶红外光谱（FT—IR）、核磁共振（1H-NMR）、热重（TG）和X粉末衍射（XRD）等技术表征了产物的化学结构、热稳定性和结晶行为。并通过紫外光谱（UV）分析了产物对5-FuOH的接枝率及其体外释药行为。结果表明，SUCS和5-FuOH间通过酯键化学键合，接枝率（载药率）为18．7％，在模拟体液和酶存在条件下均有良好的缓释性能。
英文摘要：
Chitosan coupling drug-loading body （SUCS-S-FuOH） was prepared with homemade succinyl chi tosan （SUCS） and hydroxymethyl-5-fluorouracil （5 Fu（）H） as materials. The chemical structure, thermal sta- bility and crystallization behavior of the obtained sample were characterized by Fourier infrared spectrum （FT IR）, nuclear magnetic resonance （＇H NMR）, thermal gravimetric analysis （TC-） and X-ray powder diffraction （XRD）. The grafting rate of 5 FuOH and the in vitro releasing performance were analysed by UV spectrum （UV）. The results indicated that SUCS and 5-FuOH were chemically bonded through ester linkage, the graft ing rate （drug loading rate） of SUCS-5-FuOH was 18.7%, and it had good sustained release performance under the condition of simulated body fluids and enzymes.
同期刊论文项目
同项目期刊论文
Preparation of PVDF membranes via the low-temperature TIPS method with diluent mixtures: The role of
Understanding PVDF ultrafiltration membrane fouling behavior through model solutions and secondary w
Preparation of PVDF hollow fiber ultrafiltration membrane via phase inversion/chemical treatment met
Study on the effect of modified PVDF ultrafiltration membrane for secondary effluent of urban sewage
The effect of PVDF concentration on PVDF/woven tube composite membranes and the application of compo
ExperimentalStudy of Adhesion Properties Between Membrane Surface and Humic Acid DuringMicrofiltrati
Mechanism analysis of membrane fouling behavior by humic acid usingatomic force microscopy: Effect o
Polyvinylidene fluoride/poly(ethylene-co-vinyl alcohol) blended membranes and a systematicinsight in
Enhancement and Mitigation Mechanisms of Protein Fouling of Ultrafiltration Membranes underDifferent
Preparation of a polyvinylidene fluoride membrane material probe and its application in membrane fou
Study of antifouling modified ultrafiltration membrane based on the secondary treated water of urban
期刊信息
位置：