目的:对接受美沙酮维持治疗的海洛因成瘾者骨质疏松情况进行研究。方法:采用横断面调查研究方法,有32名接受美沙酮维持治疗的患者,用双能X光骨密度仪(HolgieQDR-2000)测定骨密度。结果:双能X光测得的骨密度结果显示,有78.1%(25/32)的受试者骨密度值低于正常值范围,其中有53.1%(17/32)的受试者T〈-2.5,25.O%(8/32)的受试者-1.0〉T〉-2.5。在测试前没有受试者被诊断为骨质疏松,没有受试者接受抗骨质疏松治疗。相关性分析发现:女性发生骨密度值降低的比例明显高于男性(P〈0.05),体重与骨密度值成正相关(P〈0.05),海洛因使用时间与骨密度值成负相关(P〈0.05)。结论:接受美沙酮维持治疗的人群中骨质疏松发生率高于正常人群。该结果提示,应该增强美沙酮维持治疗人群的骨质疏松筛查及治疗,以降低骨质疏松骨折发生的风险。
Objective:To examine the frequency and severity of low bone mineral density(BMD) among heroin addicts enrolled in a methadone maintenance treatment(MMT) program. Methods : Cross- sectional design was used in the study. BMD was measured by dual energy X -ray absorptiometry (DXA). Results:DXA results were below normal in 78. 1% (25/32)of the study sample with T - scores 〈 - 2.5 ( osteoporosis range) in 53. 1% (17/32) and.between - 1.0 and - 2.5 ( osteopenia range) in 25.0% (8/32). None of the participants reported a known diagnosis of osteoporosis. bivariate analyses, significant predictors of low BMD were : female gender ( P 〈 0.05 ), lower weight ( P 〈 0.05 ), and duration of heroin use( P 〈 0.05 ). Conclusion:The morbidity of osteoporosis is significantly higher in the heroin addicts in MMT program. Efforts to increase awareness of low BMD in MMT patients should be considered so that effective treatment may be employed to lower future fracture risk.